奈米材料&生醫實驗室


Nanomaterials&Biomedicine Laboratory


(Hui-Fen Wu's Group)


吳慧芬老師


中山大學化學系專任教授


中山大學特聘教授 中山大學醫學科技究所合聘教授


中山大學海洋生物科技博士學程合聘教授 高雄醫學大學藥學系合聘教授


E-mail: hwu@faculty.nsysu.edu.tw 高雄市鼓山區蓮海路 70 號,國立中山大學化學系 獎勵/榮譽:

中山大學 103~104, 104~107, 107~108 學年度特聘教授 台灣化學感測器科技協會 105 年度學術傑出獎

2017 馬奎斯世界名人錄之終身成就獎

亞太材料學會 2017 年會貢獻獎

亞太材料學會 2017 年 keynote 演講績優獎

女性科技人才培育之科學活動，獲頒感謝狀(2016-2017)

105 年教育部資深優良教師獎

2012 國際傑出發明家獎-學術國光獎章

台灣化學感測器科技協會 103 年度傑出論文獎

中山大學 102 學年度研究傑出獎

中山大學 101 年論文被引用獎勵

中山大學 102,101,100 年學術研究績優教師

97,99,101,102~107 年國立中山大學化學系研究績優獎

2007-2012 國立中山大學研究獎勵

2009 年國立中山大學教學研究獎勵

1997-2006 淡江大學專題研究成效卓著獎

1997-2006 淡江大學研究獎勵

1997 年國科會甲等研究獎

Marquis Who's Who (2009, 2018)

30th Pearl Anniversary Edition of Who’s Who in the World2013, 2014 Who's Who in the World-distinguishes as a star

Hobby: Playing violin relaxing music (小提琴舒壓音樂).


Our Lab provides excellent environment to cultivate young scientists. We have been working on synthesis of novel /new nanomaterials for medical application such as diagnosis and treatment of cancer and brain diseases. Current, we have lab members including 1 post-docs, 4

PhD students, 3 master students and 3 part time research assistantｓ. we welcome new

graduate students to join our lab. Our Lab provides excellent research topics ｆｏｒ ｓｔ ｕｄｅｎｔｓ. Beside, graduate students do not have to run Lab duty. Our part time research

assistants and teacher can carry lab dutｙ so that students and post-doc can focus on research.

Our previous foreign members have found excellent job in academic field. Our Taiwan master students also can find excellent job in industry because our Lab has many advanced instruments that can train students for relative ability. If you would like to know more about our lab work, you can contact teacher for visiting our lab: hwu@faculty.nsysu.edu.tw.


我們的實驗室為培養年輕人提供了良好的環境。我們致力於合成用於醫療應用的新型納米材 料，例如癌症和腦部疾病的診斷和治療。目前我們實驗室成員包括 1 名博士後，4 名博士生， 3 名碩士生和 3 名兼職研究助理。我們歡迎新的研究生加入我們的實驗室。我們的實驗室提供 優秀的研究課題。除此之外，我們的兼職研究助理和老師可以承擔實驗室 duty，以便學生和 博士後能專注於研究。實驗室的外國成員都可以在學術上找到出色的工作; 台灣碩士生也可以 在儀器行業中找到好的工作，因為實驗室有很多的儀器可以培養學生良好的能力。如果您想更 多了解我們實驗室，可以聯繫老師&訪問我們的實驗室：hwu@faculty.nsysu.edu.tw。


目前研究:


奈米生物醫學


合成新的奈米中孔洞/碳量子點,Graphene Quantum Dots 複合材料應用在藥物傳輸於多類型 的癌症治療，如:胰臟癌,腦癌，乳癌，肝癌,肺癌治療,及神經科學疾病的研究(如:阿茲海默症)

奈米粒子在奈米藥物系統的開發.

SERS-Raman 生物反應器


癌症診斷/治療分析法


癌症幹細胞檢測及奈米粒子治療癌症研究.

功能性碳量子點(Carbon nanodots)於藥物傳輸(drug delivery)&癌症治療 功能性 Graphene 奈米粒子於藥物(drug delivery)&癌症治療

SERS-Raman 生物反應器快速檢驗癌症 海洋生物科技 污染/水質分析,Hg,毒物分析


更多實驗室詳細資訊請參考以下連結 (Link to below for more information):


主要儀器介紹 (Introduction of ESI-MS and MALDI-MS) 實驗室儀器設備 (Selective Lab Instruments) 實驗室成員及相片 (Lab Members and Photos) 實驗室成員論文及榮譽 (Lab Member’s Thesis and Honors)

Our Lab work has been focused on Nano-Biomedicine and medical projects using nanotechnology.The current interests are: (1) Developing drug delivery techniques using nanotechnology for various cancer treatment such as pancreas, brain and breast cancers.(2) Early diagnosis of cancer stem cells. (3) Nanotechnology for pathogenic bacteria analysis. (4) Novel methods for medical technology. (5) Marine biotechnology for metal pollution analysis. Our lab welcomes motivated applicants from Taiwan and international countries for post-doc,

PhD, master and undergraduate students. Ｔｈｅ Ｌab principle investigator and senior

members provide excellent role models and many novel research fields/topics for junior students. We also have excellent team work with Lab members． Our working time is also quite free flexible that encoureges members to build up creactivity from diversed learning on crossed field research.This is an excellent Lab to build up students with great scientific interests and excellent scientific ability for young scientists. Taiwan students also can build up excellent English ability without going to USA. Contact Prof. Wu for admission details: hwu@faculty.nsysu.edu.tw.

我們的實驗室工作專注於使用納米技術的生物醫學和醫療項目。目前的興趣包括：（1）開發 利用納米技術進行各種癌症治療（如腦癌和乳癌）的藥物遞送技術。（2）癌症的早期診斷(幹 細胞)。 （3）納米技術用於病原菌分析。 （4）醫療技術的新方法。 （5）用於金屬污染分 析的海洋生物技術。 我們的實驗室歡迎來自台灣和國際的學生申請博士後，博士，碩士和本 科生。 實驗室ＰＩ研究員為（初級）學生提供了優秀的榜樣和許多新穎的研究領域＆主題。 我 們實驗室有優秀的合作團隊。 我們的工作時間也非常靈活，鼓勵學生通過跨領域研究的多元 化學習來增強創造力。這是一個很好的實驗室，可為年輕的學生培養科學興趣和卓越科學能力。 台灣學生也可以在不去美國的情況下，建立優秀的英語能力。 了解詳情：hwu@faculty.nsysu.edu.tw。


Book Chapters:


1. Suresh Kailasa, Hui-Fen Wu*, Comprehensive Sampling and Sample Preparation. Volume 3, Chapter title: Inorganic Contaminants: Sample Preparation Approaches. Pawliszyn, J.; Le, X. C.; Li, X-F.; Lee, H. K.; Eds; Elsevier, Academic Press: Oxford, UK, 2012, 743–782. (With author’s photo and biography).

2. Suresh Kailasa, Hui-Fen Wu*, Vaibhavkumar Mehta, Quantum Dots: Applications, Synthesis and Characterization. Chapter 5: Prospects of Engineering Quantum Dots Applications in Ultrasensitive Assays, Nova Science Publishers, 2012, 69-109.

  1. Suresh Kailasa, Hui-Fen Wu*, Cysteine: Biosynthesis, Chemical Structure and Toxicity.

    Chapter 3: Toxicity of Cysteine: Towards Biopathways. Editors: Fyodor V Chorkina, Andrey I. Karataev, Nova Science Publishers, 2012, 61-84.

  2. Suresh Kailasa and Hui-Fen Wu*, Lysozymes: Sources, Functions and Role in Disease. Chapter 5: Functions of Lysozymes and their identification of by MALDI-MS. Nova Science Publishers, 2013, 155-169.

  3. Suresh Kailasa, Hui-Fen Wu*, Shang-Da Huang*, Waste Water-Treatment Technologies and Recent Developments . Chapter 5: Recent developments on mass spectrometric techniques for pesticide analysis from waste water. In Tech Publications, 2013, 99-120. (This chapter has 1500 downloads on Dec 14, 2013).

  4. Suresh Kailasa, Karuna A. Rawat, Hui-Fen Wu*, Ionic Liquids in Bioanalysis, ebook entitled “Sample extraction techniques for biological samples: recent advances and novel applications”. Future Science Group, UK, London, 2014, accepted. (with author’s photo and biography).

  5. Suresh Kailasa, Stephanie L. D’souza, Hui-Fen Wu*, Analytical Applications of Nanoparticles

    in MALDI-MS for Bioanalysis, ebook entitled “Sample extraction techniques for biological samples: recent advances and novel applications” Future Science Group, UK, London, 2014, accepted. (with author’s photo and biography).

  6. Suresh Kailasa, Hui-Fen Wu*, Applications of Carbon Nanomaterials in Cellular Imaging for

    publication in the Multi-Volume SET (I-XI), Applications of NanoBioMaterials, Volume VIII: NanoBioMaterials in Medical Imaging, Wiley, 2014, accepted.

  7. Hani Abdelhamid, Hui-Fen Wu*, Book:Reference Module in Chemical, Molecular Sciences and Chemical Engineering, Chapter:11016, Ionic Liquid Matrices for Mass Spectrometry: Design, Synthesis,and Applications, Elsevier, 2014, accepted.

  8. Suresh Kailasa, Hui-Fen Wu*, Jignesh Kumar, Graphene Science Handbook: Applications and Industrialization. Vol. 6, Chapter title: Graphene-Based Laser Desorption/Ionization Mass Spectrometry: An Approach to Bioanalytical Applications, CRC Press/Taylor&Francis, FL, USA, 2014, in press.

  9. Suresh Kailasa, Hui-Fen Wu*, Chapter 34: Proteomic profiling by nanomaterials-based MALDI mass spectrometry - principles and examples. Book title: Analytical methods and integrated work-flows for Proteomic profiling, Springer, Germany, 2015, 479-496.

  10. Suresh Kailasa, Hui-Fen Wu*, Jignesh Kumar, Graphene Science Handbook: Applications and Industrialization. Vol. 6, Chapter title: Graphene-Based Laser Desorption/Ionization Mass Spectrometry: An Approach to Bioanalytical Applications, CRC Press/Taylor&Francis, FL, USA, 2016, in press.

  11. Suresh Kailasa, Vaibhavkumar N. Mehta, Nazim Hasan, Hui-Fen Wu*, Applications of Carbon Nanomaterials in Biosensing and Cellular Imaging, Elsevier, 2016, in press (proof 2/23-).


  12. Suresh Kailasa, Vaibhavkumar N. Mehta, Hui-Fen Wu*, Food Preservation: Nanotechnology in the Agri-Food Industry, Volume 6, Chapter 13: Recent Advances in the Direct and

    Nanomaterials –Based Matrix Assisted Laser Desorption / Ionization Mass Spectrometric Approaches for Rapid Characterization and Identification of Foodborne Pathogens, Edited by Alexandru M Grumezescu, Elsevier, 2016, 449-485.


  13. Hani Abdelhamid, Hui-Fen Wu*, Frontiers in Clinical Drug Research - Alzheimer Disorders Volum 6, Chapter 1, Biological Mass Spectrometry for Diagnosis of Alzheimer’s Disease, 2016, Vol.6, 3-22, Bentham ebooks, eBook Reference No: 9781681083391-16-1038.


  14. Hani Abdelhamid, Hui-Fen Wu*, Nanoparticles Advances drug delivery: Strategies, Pros and Cons, Nanoconjugate Nanocarriers for Drug Delivery, Apple Academic Press, worldwide distribution by CRC Press, a Taylor & Francis Group, 2017, accepted.


Patents:


Hui-Fen Wu, Suresh Kailasa, Nazim Hasan, Apparatus and method of liquid nitrogen assisted spray ionization mass spectrometry. 發明專利核准審定書(學校編號 101034TW),台灣發明專


利 No.101129644 (101/8/16 applied-103/10/28 issued).


Hui-Fen Wu, Judy Gopal, Muthu Manikandan, Nazim Hasan, Bacterio-toxicity/compatibility of Platinum nanoparticles, 2013, Jan. No.: 101081TW. 台灣發明專利.


Hui-Fen Wu, Judy Gopal, Hani Abdelhamid, Pei-Yang Hua, Chitosan nanomagnets for effective extraction and sensitive mass spectrometric detection of pathogenic bacterial endotoxin from

human urine, 2013, Mar. No: 102027TW. 台灣發明專利.

Hui-Fen Wu, Muthu Manikandan, Nazim Hasan, PK1322, 鉑奈米粒子用於製備治療癌症藥物 的用途, 發明專利核准審定書(學校編號 102028TW), Platinum nanoparticles for treatment of cancer,台灣發明專利, No.102137386 (102/10/16 applied-104/7/20 issued).


Hui-Fen Wu, Hani Abdelhamid, PK13231, 石墨烯磁性甲殼素聚合物之用途，發明專利核准


審定書 ( 學校編號 102039TW), Graphene magnetic chitosan and its use. 台灣發明專


利,No.102138937 (102/10/28 applied-104/6/17 issued).


Hui-Fen Wu, Hani Abdelhamid, Furoic Acids as new matrices for matrix assisted laser desorption/ionization mass spectrometry, Taiwan Patent applied 2013, May. 台灣發明專利


(104/9 issued).


Hui-Fen Wu, Hani Abdelhamid, 甲芬那酸為新基質 之用途 Mefenamic acids as a new


matrice for matrix assisted laser desorption/ionization mass spectrometry, Taiwan Patent, 2016, March issued. 台灣發明 專利


Publication list (期刊論文 ): *Corresponding author, citation to 2014/11/1)


2018


  1. Sunil Pandey, Krishna Sharma, Amit Sharma, Yowan Nerthigan, M Shannawaz Khan, Da-Ren Hang, Hui-Fen Wu*, Comparative photothermal performance among various sub-stoichiometric 2D oxygen deficient molybdenum oxide nano-flakes and in vivo toxicity, Chemistry-An European Journal, 2018, Accepted (IF 5.16, 37/171, Chem, Muitidisciplinary)


  2. Sunil Pandey, Amit Sharma, Krishna Sharma, Yowan Nerthigan, M Shannawaz Khan, Da-Ren Hang, Hui-Fen Wu*, Rapid naked eye detection of alkaline phosphatase using <alpha>-MoO3-x nano-flakes. Sensors & Actuators: B. Chemical, 2018, 254, 514-518 (IF5.667)


  3. Amit Sharma, Sunil Pandey, M Shannawarz Khan, Hui-Fen Wu*, Protein stabilized fluorescent gold nanocubes as selective probe for alkaline phosphatase via inner filter effect, Sensors & Actuators: B. Chemical, 2018, accepted (IF5.667).


  4. Yowan Nerthigan, Amit Sharma, Sunil Pandey, Krishna Sharma, M Shannawaz Khan, Da-Ren Hang, Hui-Fen Wu*, Glucose oxidase assisted visual detection of glucose using oxygen deficient

    α-MoO3-x nanoflakes Microchimica Acta, 2018, accepted. (IF5.705, 7.5%,Chemistry, Analytical).


  5. Hani Abdelhamid, Yu-Chih Lin, Hui-Fen Wu*, Selective Biosensing of Staphylococcus Aureus Using Chitosan Quantum Dots, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 188, 50-56 (IF2.536).

  6. Manikandan Muthu , Hui-Fen Wu , Judy Gopal , Iyyakkannu Sivanesan, Se Chul Chun*, Exploiting Microbial Polysaccharides for Biosorption of Trace Elements in Aqueous Environments – Scope for Expansion via Nanomaterial Intervention, Polymers (MDPI), 2018, accepted (IF:5Y: 4.33).


  7. Amit Kumar Sharma; Sunil Pandey, Yowan Nerthigan; M. Shahnawaz Khan; Da-Ren Hang; Hui-Fen Wu*, Two dimensional <alpha>-MoO3-x nanoflakes as bare eye probe for hydrogen peroxide in biological fluids, Analytical Chimia Acta, 2018, Accepted (I.F5.123,7/76,9.2%,Chemistry,Analytical).


  8. Amit Kumar Sharma; Sunil Pandey, Yowan Nerthigan, Nandini, Hui-Fen Wu*, Aggregation of cysteamine-capped gold nanoparticles in presence of ATP as an analytical tool for rapid detection of creatine kinase, Analytical Chimia Acta, 2018, Accepted (I.F.: 5.123, 7/76,9.2%,Chemistry,Analytical).


  9. Manikandan Muthu, Sechul Chun, Hui-Fen Wu, Mark W Duncan* and Judy Gopal*, The Ongoing Evolution of Laser Desorption/Ionization Mass Spectrometry: Some Observations on Current Trends and Future Direction, Journal of mass spectrometry, 2018, Accepted (Cover story, IF 2.381. 16/42, 38.09%, Spectroscopy).


  10. Mohd Nawaz, Hui-Fen Wu*, Rapid communication in mass spectometry, 2018, Accepted.

2017


  1. Mukesh Bhaisare, Shahnawaz Khan, Sunil Pandey, Gangaraju Gedda, Hui-Fen Wu*,

    Shape-oriented photodynamic therapy of cuprous oxide (Cu2O) nanocrystals for cancer treatment.

    RSC-Advances, 2017, 7, 23607-23614 (I.F.: 3.108/ 5Y:3.257,59/166,35.5%,Chemistry,

    Multidisciplinary).


  2. Sekar Kumaran, Hani Abdelhamid, Hui-Fen Wu*,Quantification analysis of protein and mycelium contents upon inhibition of melanin for Aspergillus Niger: A study of matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS), RSC-Advances, 2017, 7, 30289-30294 (I.F.: 3.108/ 5Y:3.257,59/166,35.5%,Chemistry, Multidisciplinary) .


  3. Sunil Pandey, Gangraju Gedda, Mukesh T, Mukesh L Bhaisare, Abou Talib, Shahnawaz Khan, Shou-Mei Wu, Hui-Fen Wu*, Theranostic Carbon Dots 'Clathrate-like' nanostructures for targeted photo-chemotherapy and bioimaging of cancer, Journal of Industrial and Engineering Chemistry, 2017, 56, 62-73 (I.F.: 4.421, 14/135,10%,Engineering, Chemical).


  4. Hani Abdelhamid, Abou Talib, Hui-Fen Wu*, One pot synthesis of gold - carbon dots nanocomposite and its application for cytosensing of metals for cancer cells. Talanta, 2017, 166, 357-363 (I.F.: 4.162, 9/76,11.8%,Chemistry,Analytical) Citation: 1.


  5. Hani Abdelhamid, Yu-Chih Lin, Hui-Fen Wu*, Thymine Chitosan Nanomagnets for Specific Preconcentration of Mercury (II) prior to Analysis Using SELDI-MS, Microchimica Acta, 2017, May, 184(5), 1517-1527 (I.F.: 4.58, 8/76,10.5%,Chemistry,Analytical) Citation: 1


  6. Cheng-Yu Chen, Hani Abdelhamid, Hui-Fen Wu*, Surface tuning laser desorption/ionization mass spectrometry (ST-LDI/MS) for small molecule bioanalysis using quantum dots. Analytical and

    Bioanalytical Chemistry, 2017, Aug, 409(21), 4943-4950 (I.F.: 3.431, 16/76,21%,Chemistry,Analytical)


  7. Yuan-Chin Chen, Hani Abdelhamid, Hui-Fen Wu*, Simple and Direct Quantitative Analysis for Quinidine Drug in Fish Tissues. Mass Spectrometry Letters, 2017, 8(1), 8-13.


  8. Hani Abdelhamid, Yu-Chih Lin, Hui-Fen Wu*, Magnetic Nanoparticles Modified Chitosan for Surface Enhanced Laser Desorption/Ionization Mass Spectrometry for Surfactants, RSC Advances, 2017, 7, 41585 – 41592.


  9. Khan, Shahnawaz Khan, Abou Talib, Sunil Pandy, Mukesh Bhaisare, Gangaraju Gedda, Hui-Fen Wu*, Folic Acid navigated Silver Selenide nanoparticles for photo-thermal ablation of cancer cells, Colloids and Surfaces B: Biointerfaces, 2017, 159, 564-570


  10. Khan, Hui-Fen Wu*, Graphene oxide@gold nanorods for chemo-photothermal treatment and controlled release of doxorubicin in mice Tumor, Colloids and Surfaces B: Biointerfaces, 2017, 160, 543-552.


2016


  1. Sunil Pandey, Abou Talib, M. Mukeshchand Thakur, M. Shahnawaz Khan, Mukesh Lavkush Bhaisare, Gangaraju Gedda, Hui-Fen Wu*, Tellurium Platinate Nano-worms for Photo-thermal and photodynamic therapy of Cancer cells: A paradigm shift in treatment of cancer cells using composite metal alloys, Journal of Materials Chemistry B, 2016, accepted.


  2. Mukesh Bhaisare; Gangaraju Gedda; Shahnawaz Khan; Hui-Fen Wu*, Fluorimetric detection of pathogenic bacteria using Magnetic carbon dots", Analytical Chimia Acta, 2016, accepted.


  3. Hani Abdelhamid*, Hui-Fen Wu*, Gold nanoparticles assisted laser desorption/ionization mass spectrometry and applications: from simple molecules to intact cells, Analytical and Bioanalytical Chemistry, 2016, accepted.


  4. Muthu Manikandan, Hui-Fen Wu*, Bio-mimicked gold nanoparticles with complex fetal bovine serum as sensors for single cell MALDI MS of cancer cell and cancer stem cell. Sensors & Actuators: B. Chemical, 2016, accepted (IF4.097/4.286, 3/56, 5.36%.).


  5. Judy Gopal, Hani Abdelhamid, Jhih-Huan Huang, Hui-Fen Wu*, Nondestructive detection of the freshness of fruits and vegetables using gold and silver nanoparticle mediated graphene enhanced Raman spectroscopy. Sensors & Actuators: B. Chemical, 2016, Mar, 224, 413-424 (IF4.097/4.286, 3/56, 5.36%.).


  6. Gangaraju Gedda, Chun-Yi Lee, Yu-Chih Lin, Hui-Fen Wu*, Green synthesis of Carbon dots from prawn shells for highly selective and sensitive detection of copper ions, Sensors & Actuators: B. Chemical, 2016, Mar, 224, 396-403 (IF4.097/4.286, 3/56, 5.36%.).


  7. Mukesh L. Bhaisare, Bo-Sgum Wu, Mon-Chun Wu, Mei-Hwuy Tseng, Hui-Fen Wu*, MALDI MS analysis, disk diffusion and optical density measurements for antimicrobial effect of Zinc

    Oxide nanorods integrated in Graphene Oxide nanostructures. 2016, 4 (1), 183-194,

    Biomaterials Science (RSC), (IF3.831/3.831, 10/33, materials science, biomaterials).


  8. Gangaraju Gedda, Sunil Pandey, M Shahnawaz Khan, Abou Talib, Hui-Fen Wu*, Novel synthesis of porous titanium oxide for drug delivery of vinorelbin bitartrate, RSC Advances, 2016, 6, 13145-13151 (IF3.84/3.907).


  9. Nazim Hasan, Nawaz Mohd, Hui-Fen Wu*, CoFe2O4-ZnO Nanoparticles for rapid microwave assisted tryptic digestion of phosphoprotein and phosphopeptides analysis in Matrix Assisted Laser Desorption /Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2016, Accepted.


  10. M Shahnawaz Khan, Mukesh L Bhaisare, Judy Gopal, Hui-Fen Wu*, Highly efficient Gold nanorods assisted Laser phototherapy for rapid treatment on mice wound infected by pathogenic bacteria, Journal of Industrial and Engineering Chemistry (Elsevier). 2016, Accepted (IF3.512/3.021).

11. M Shahnawaz Khan, Mukesh L Bhaisare, Judy Gopal, Hui-Fen Wu*, Highly efficient Gold

nanorods assisted Laser phototherapy for rapid treatment on mice wound infected by pathogenic bacteria, Journal of Industrial and Engineering Chemistry (Elsevier). 2016, Accepted (IF3.512/3.021).

  1. Abou Talib, M Shahnawaz Khan, Gangaraju Gedda, Hui-Fen Wu*, Stabilization of Gold Nanoparticles using Natural Plant Gel: A greener step towards biological applications, Journal of Molecular Liquids, 2016, Accepted (IF2.5)

  2. Abou Talib, Hui-Fen Wu*, Biomimetic synthesis of Lotus leaf extract-assisted silver

    nanoparticles and shape-directing role of cetyltrimethylammonium bromide, Journal of Molecular Liquids, 2016, Accepted (IF2.5)

  3. Bo-Sgum Wu, Judy Gopal, Pei-Yang Hua, Hui-Fen Wu*, Graphene nanosheet mediated

    MALDI-MS (GN-MALDI-MS) for rapid, in situ detection of intact incipient biofilm on material surfaces, Materials Science & Engineering C, 2016, Accepted.

  4. Nazim Hasan, Zhongxian Guo, Hui-Fen Wu*, Large protein analysis of Staphylococcus aureus

    and Escherichia coli by MALDI TOF mass spectrometry using amoxicillin functionalized magnetic nanoparticles, Analytical and Bioanalytical Chemistry, 2016, accepted, (IF3.5).

  5. Mukesh L. Bhaisare, Krishna Hari Sharma, Jun-Yi Lee, Da-Ren Hang, Hui-Fen Wu*,Synthesis

    of two-dimensional Molybdenum oxide nanoflakes with various phases and their nano-based characterization, New Journal of Chemistry, 2016, Accepted.

  6. Hani Abdelhamid, Sekar Kumaran, Hui-Fen Wu*,One-pot synthesis of CuFeO2 nanoparticles

capped with glycerol and proteomic analysis of their nanocytotoxicity against fungi, RSC Advances, 2016, Accepted.


2015


  1. Gangaraju Gedda, Sunil Pandey, Yu-Chih Lin, Hui-Fen Wu*, Antibacterial effect of calcium oxide Nano-plates fabricated from Shrimp shells. Green Chemistry, 2015, 17 (6), 3276-3280 (IF8.02).

  2. Suresh K Kailasa, Hui-Fen Wu*, Nanomaterials-based miniaturized extraction and preconcentration techniques coupled with matrix-assisted laser desorption/ionization mass spectrometry for biomolecules assays, Trends in Analytical Chemistry, 2015, Feb, 65, 54-72. (IF6.612/5Y:7.311, 2/76=2.63%).


  3. Hani Abdelhamid*, Hui-Fen Wu*, Proteomic analysis of the mode of antibacterial action of nanoparticles and their interactions with proteins, Trends in Analytical Chemistry, 2015, Feb, 65, 30-46. (IF6.612/5Y:7.311, 2/76=2.63%).


  4. M. Shahanwaz Khan, Hani Abdelhamid, Hui-Fen Wu*, Near infrared (NIR) laser mediated surface activation of graphene oxide nanoflakes for efficient antibacterial, antifungal and wound healing treatment, Colloids and Surfaces B: Biointerfaces, 2015, accepted. (IF4.287/5Y:4.226).


  5. M. Shahanwaz Khan, Sunil Pandey, Hui-Fen Wu*, Controlled delivery of dopamine hydrochloride using surface modified carbon dots for Neuro diseases, Colloids and Surfaces B: Biointerfaces, 2015, accepted. (IF4.287/5Y:4.226).


6. Hani Abdelhamid, Hui-Fen Wu*, Synthesis of highly dispersive sinapinic acid @ graphene oxide (SA@GO) and their applications as a novel surface assisted laser desorption/ionization mass spectrometry for proteomics and pathogenic bacteria biosensing, Analyst, 2015, 140, 1555-1565, (IF3.906/4.097, 7/76=9.21%)


  1. Sunil Pandey, Mukeshchand Thakur, Abu Talib, M. Shahanwaz Khan, Mukesh Lavkush Bhaisare, Gangaraju Gedda, Shou-Mei Wu, Hui-Fen Wu*, Laser assisted synthesis of

    Multi-colored Protein dots and their biological distribution in mice using Dye tracking method: A novel approach to deliver therapeutic payloads to central nervous system, RSC-advances, 2015, 5 (6), 4051-4057 (IF3.708/3.708).


  2. Judy Gopal, Hui-Fen Wu*, A brief case study demonstrating the applicability of MALDI Mass Spectrometry for detecting bacteria in dental samples, RSC Advances, 2015, 5, 14090-14094 (IF3.708/3.708).


  3. Mukesh L. Bhaisare, Sunil Pandey, M. Shawan Khan, Abu Talib, Hui-Fen Wu*, Fluorophotometric Determination of Critical Micelle Concentration (CMC) of Ionic and

    Non-ionic Surfactants with Carbon Dots via Stokes Shift, Talanta, 2015, 132, 572-578, (IF3.794, 12/73, 16.44%, Chemistry, Analytical).


  4. Suresh Kumar Kailasa, Hui-Fen Wu*, Electrospray ionization tandem mass spectrometry for rapid, sensitive and direct detection of melamine in dairy products, Journal of Industrial and Engineering Chemistry (Elsevier), 2015, Jan., 21, 138-144 (IF2.145).


  5. Nadeem Khan, Hani Nasser Abdelhamid, Ja-Yi Yan, Fon-Tsai Chung, Detection of Flutamide in pharmaceutical dosage using higher electrospray ionization mass spectrometry (ESI-MS) tandem mass coupled with Soxhlet apparatus, Analytical Chemistry Research (Elsevier), 2015, Accepted.(IF2.0).


  6. Judy Gopal, Muthu Manikandan, Hui-Fen Wu*, State of the art nano-platform integrated MALDI-MS impacting resolutions in urinary proteomics, Proteomics Clinical Applications, 2015, accepted.(IF2.6). (Review paper).


  7. Hani Abdelhamid, Hui-Fen Wu*, Reduced graphene oxide conjugate thymine (T@rGO) as a new probe for ultrasensitive and selective fluorometric determination of mercury (II) ions, Microchimica Acta, 2015 accepted. (IF3.7).


  8. Judy Gopal, Jararn LN, Khan Shan, Hui-Fen Wu*, MALDI mass spectrometry for probing the anti- Staphylococcal capability of TiO2 nanoparticles via near-UV and laser irradiation, New Journal of Chemistry, 2015, 39, 4909-4918.(IF3.159).


  9. Mukesh L. Bhaisare, Hani Abdelhamid, Hui-Fen Wu*, Facile synthesis of water soluble silver ferrite (AgFeO2) nanoparticles and their biological application as antibacterial agents,

    RSC-advances, 2015, accepted. (IF3.708).


  10. Lokesh A, Hani Abdelhamid, Mohd Nawaz, Hui-Fen Wu*, Synthesis, characterization and bifunctions of bidentate silver nanoparticle assisted single drop microextraction as a highly sensitive preconcentrating probe for protein analysis , RSC-advances, 2015, 5, 41595-41603. (IF3.708).


  11. Hani Abdelhamid, Hui-Fen Wu*, Synthesis and Multifunctional Applications of Quantum Nanobeads for Label-Free and Selective Metals Chemosening, RSC Advances, 2015, 5, 50494-50504 (IF3.708/3.708).


  12. Mukesh L. Bhaisare, Hui-Fen Wu*, Synthesis of fluorescent carbon dots via microwave carbonization of citric acid in presence of tetraoctylammonium ion and their application to cellular bioimaging. Microchimica Acta, 2015, accepted. (IF3.7).


  13. Hani Abdelhamid, Hui-Fen Wu*, Soft Ionization of Metallo-Mefenamic using Electrospray Ionization Mass Spectrometry. Mass Spectrometry Letters, 2015, accepted.


  14. Suresh Kumar Kailasa, Hui-Fen Wu*, Ionic Liquids in Bioanalysis, Bioanalysis, 2015, accepted. (IF3.027/3.04).


  15. Suresh Kumar Kailasa, Hui-Fen Wu*, Analytical Applications of Nanoparticles in MALDI-MS for Bioanalysis, Bioanalysis, 2015, accepted (IF3.027/3.04).


  16. Hani Abdelhamid, Hui-Fen Wu*, Synthesis, Characterization of Quantum Dots and Application in Laser Soft Desorption/Ionization for Labile Metal-Drug Interactions and their Antibacterial Activity, RSC Advances, 2015, Sep, 5, 76107-76115 (IF3.84/3.907).


  17. M. Shahanwaz Khan, Mukesh Lavkush Bhaisare, Sunil Pandey, Abu Talib, Suresh K Kailasa, Shou-Mei Wu, Hui-Fen Wu*, Exploring the ability of Water Soluble Carbon dots as matrix for

    detecting neurological Disorders using MALDI-TOF MS, International Journal of Mass Spectrometry, 2015, Accepted.


  18. M Shahnawaz Khan, Mukesh L Bhaisare, Judy Gopal, Hui-Fen Wu*, Highly efficient Gold nanorods assisted Laser phototherapy for rapid treatment on mice wound infected by pathogenic bacteria, Journal of Industrial and Engineering Chemistry (Elsevier). 2015, Accepted (IF3.512/3.021).


  19. A biographical Memoir by Gabor A. Somorjai for Leo Brewer, 2015, Former Brewer post-doc Hui-Fen Wu recalls Brewer, Proceedings of the National Academy of Sciences, 2015, Accepted.


2014


  1. Muthu Manikandan, Hani Abdelhamid, Abu Talib, Hui-Fen Wu*, Facile synthesis of gold nanohexagons on graphene templates in Raman spectroscopy for biosensing cancer and cancer stem cells, Biosensors and Bioelectronics, 2014, May, 55, 180-186. (IF6.451, 1/26, 3.85%, Electrochemistry, 4/73, 5.48%, Chemistry, Analytical).(This paper has been downloaded or viewed 605 times (in 40 days) since publication on line on Nov.21, 2013 to Dec.31, 2013).Times cited 1.


  2. Pei-Yang Hua, Muthu Manikandan, Hani Abdelhamid, Hui-Fen Wu*, Graphene nanoflakes as efficient ionizing matrix for MALDI MS based lipodomics of cancer cells and cancer stem cells, Journal of Materials Chemistry B, 2014, 2 (42) 7334-7343. (IF6.626/5Y:6.743).


  3. Mukesh L. Bhaisare, Hani Abdelhamid, Bo-Sgum Wu, Hui-Fen Wu*, Rapid and direct MALDI-MS identification of pathogenic bacteria from blood via ionic liquid-modified magnetic nanoparticles (Fe3O4@SiO2), Journal of Materials Chemistry B, 2014, 2 (29), 4671-4683 (IF6.626/6.743, 16/225, 7.11%, Materials Science, Multidisciplinary, a journal in biology and medicine).


  4. Steve Haga, Hui-Fen Wu*, Overview of software options for processing, analysis and interpretation of mass spectrometric proteomic data, Journal of mass spectrometry, 2014, Oct, 49 (10), 959-969 (IF3.289, 8/42, 19.05%, Spectroscopy). (Special feature article-perspective, journal cover, author biography 特寫文章-觀點論文/封面報導/作者介紹).


  5. Hani Abdelhamid, Hui-Fen Wu*, Polymer dots for quantifying the total hydrophobic pathogenic lysates in a single drop. Colloids and Surfaces B: Biointerfaces (Elsevier), 2014, Mar, 115,

    51-60 (IF3.55). (This paper has been downloaded or viewed 366 times since publication).Times

    cited 3.


  6. Hani Abdelhamid, M. Shawan Khan, Hui-Fen Wu*, Design, characterization and applications of new ionic liquid matrices for multifunctional analysis of biomolecules: a novel strategy for

    pathogenic bacteria biosensing, Analytica Chimica Acta, 2014, May, 823, 51-60 (IF 4.555, 5/73,

    6.85%).Times cited 1.


  7. Hani Abdelhamid, Hui-Fen Wu*, Ultrasensitive, rapid and selective detection of mercury using graphene assisted laser desorption/ionization mass spectrometry, Journal of The American Society for Mass Spectrometry, 2014, May, 25 (5), 861-868. (IF3.594). Times cited 2.


  8. Hui-Fen Wu*, Suresh Kailasa, Ja-Yi Yen, Chen-Che Chin, Hsin-Yi Ku, Comparison of SDME with MVPE directly coupled with capillary electrophoresis for extraction and separation of tricyclic antidepressant drugs. 2014, 20, 2071-2076, Journal of Industrial and Engineering Chemistry (Elsevier). (IF2.145).


  9. Vaibhavkumar Mehta, Suresh Kailasa and Hui-Fen Wu*, Surface Modified Quantum Dots as Effective Fluorescent Probes for Biomolecule Recognition, Journal of Nanoscience and Nanotechnology, 2014, Jan, 14 (1), 447-459 (with Author Photos and Author Biographies,

    作者介紹).Times cited 2.


  10. Suresh Kailasa, Hui-Fen Wu*, Advances in nanomaterial-based microwaves and infrared wave-assisted tryptic digestion for ultrafast proteolysis and rapid detection by MALDI-MS,

    Combinatorial Chemistry & High Throughput Screening (Bentham Science), 2014, Jan, 17 (1) 68-79 (IF1.785).


  11. Anandkumar Balakrishnan, Steve W. Haga, Hui-Fen Wu*, Computer Applications Making Rapid Advances in High Throughput Microbial Proteomics (HTMP), Combinatorial Chemistry

    & High Throughput Screening (Bentham Science), 2014, Feb,17(2), 173-182 (IF1.785).


  12. Hani Abdelhamid, Mukesh Bhaisare, Hui-Fen Wu*, Ceria nanocubic-ultrasonication assisted dispersive liquid-liquid microextraction coupled with matrix assisted laser desorption/ionization mass spectrometry for pathogenic bacteria analysis, Talanta, 2014, Mar, 120, 208-217 (IF3.794, 12/76, 15.79%, Chemistry, Analytical). (This paper has been downloaded or viewed 190 times since publication on line on Dec.11, 2013 to Feb.28, 2014).Times cited 2.


  13. Bo-Sgum Wu, Hani Abdelhamid, Hui-Fen Wu*, Preparation and antibacterial performance of graphene decorated stannous dioxide, RSC-Advances, 2014, 4 (8), 3722-3731 (IF3.7). Times

    cited 3.


  14. Judy Gopal, Muthu Manikandan, Hui-Fen Wu*, Low cost Aluminium foil platforms for extraction of proteins for rapid mass spectrometric differentiation of the fungal pathogen Aspergillus niger mycelium and spores by In situ gold nanosphere accelerated microwave digestion. RSC-Advances, 2014, 4 (21), 10982-10989.(IF3.708).


  15. Suresh Kumar Kailasa, Hui-Fen Wu*, Recent developments of liquid-phase microextraction techniques directly combined with ESI- and MALDI- mass spectrometric techniques for organic and biomolecule analysis. RSC-Advances, 2014, 4 (31), 16188-16205.(IF3.708)

  16. Hani Abdelhamid, Bo-Sgum Wu, Hui-Fen Wu*, Graphene coated silica applied for high ionization matrix assisted laser desorption/ionization mass spectrometry: A novel approach for environmental and biomolecule analysis, Talanta, 2014, Aug, 126, 27-37 (IF3.794, 12/76, Chemistry, Analytical).


  17. Suresh Kumar Kailasa, Hui-Fen Wu*, Recent developments in nanoparticle-based MALDI mass spectrometric analysis of phosphoproteomes. Microchimica Acta, 2014, July, 181 (9-10),

853-864. (IF3.719, 9/76, 11.84%, Chemistry, Analytical).


18. Tzu-Yu Pan, Chun-Chi Wang, Chi-Jen Shih, Hui-Fen Wu, Shyh-Shin Choiu*, Shou-Mei Wu*,

Genotyping of intron 22 inversion of factor VIII gene for diagnosis of hemophilia A by inverse-shifting polymerase chain reaction and capillary electrophoresis, Analytical and

Bioanalytical Chemistry, 2014, Sep, 406 (22), 5447-5454 (IF3.578/5Y:3.744, 11/76, 14.47%).


  1. Muthu Manikandan, Judy Gopal, Nazim Hasan, Hui-Fen Wu*, A nano-patterned self assembled monolayer (SAM) rutile titania cancer chip for rapid, low cost, highly sensitive, direct cancer analysis in MALDI-MS, Talanta, 2014, Dec,130, 78-89 (IF3.511/5Y:3.756, 12/76, 15.78%,

    Chemistry, Analytical).

  2. Gangaraju Gedda, Sunil Pandey, Mukesh L. Bhaisare, Hui-Fen Wu*, Carbon dots as nanoantennas for anti-inflammatory drug analysis using surface-assisted laser desorption/ionization mass spectrometry in serum, RSC-advances, 2014, 4 (72), 38027-38033.(IF3.708/5Y:3.708).


  3. Muthu Manikandan, Hui-Fen Wu*, Rapid endophytic bacterial detection by enzyme incorporated MALDI MS, RSC Advances, 2014, Aug, 4 (91), 50233-50240 (IF3.708).


  4. Gangaraju Gedda, Hani Abdelhamid, M. Shawan Khan, Hui-Fen Wu*, ZnO nanoparticle modified polymethyl methacrylate assisted dispersive liquid-liquid micro extraction coupled MALDI-MS for rapid pathogenic bacteria analysis, RSC Advances, 2014, Aug, 4 (86), 45973-45983 (IF3.708).


  5. Hani Abdelhamid, Hui-Fen Wu*, Graphene oxide as a nanocarrier for gramicidin (GOGD) for high antibacterial performance. RSC Advances, 2014, Oct, 4 (91), 50035-50046 (IF3.708).


  6. Hani Abdelhamid, Hui-Fen Wu*, Monitoring the metallofulfenamic – bovine serum albumin interactions: A novel method for metallodrug analysis. RSC Advances, 2014, 4, 53768-53776 (IF3.708/3.078).


  7. Hani Abdelhamid, Hui-Fen Wu*, Facile synthesis of nano silver ferrite (AgFeO2) modified with chitosan applied for biothiols separation, Materials Science and Engineering C (Materials for Biological Applications), 2014, Dec, 45, 438-445, (IF2.736/5Y:3.076).


  8. Vaibhavkumar N. Mehta, Suresh Kumar Kailasa*, Hui-Fen Wu, Sensitive and selective colorimetric sensing of Fe3+ ion by using p-amino salicylic acid dithiocarbamate functionalized gold nanoparticles, New Journal of Chemistry (RSC), 2014, 38(4), 1503-1511. (IF2.966)

  9. M. Shawan Khan, Judy Gopal, Hui-Fen Wu*, Probing the cytotoxicity of CdS-MPA and CdSe-MUA QDs on the bacterial pathogen Staphylococcus aureus using MALDI-MS, Analytical Methods (RSC), 2014, May, 6 (14), 5304-5313 (IF1.938).


  10. Nazim Hasan, Judy Gopal, Hui-Fen Wu*, Surface pretreatment effects on titanium chips for the adhesion of pathogenic bacteria in the MALDI-MS, Applied Surface Science (Elsevier), 2014, Sep, 314, 56-63 (IF2.112/5Y:2.099).


  11. Ramaiyan Sekar, Suresh Kailasa, Yuan-Chin Chen, Hui-Fen Wu*, Electrospray ionization tandem mass spectrometric studies to probe the interaction of Cu(II) with amoxicillin. Chinese Chemical Letters (Elsevier), 2014, Jan, 25 (1), 39-45. (IF1.21).


  12. Suresh Kailasa, Hui-Fen Wu*, Rapid quantification of efavirenz in human plasma by electrospray ionization tandem mass spectrometry, Journal of the Chinese Chemical Society, 2014, Apr, 61(4), 437-441.


2013


  1. Muthu Manikandan, Nazim Hasan, Hui-Fen Wu*, Platinum nanoparticles for photothermal treatment of neuro 2A cancer cells, Biomaterials, 2013, July, 34,

    5833-5842 (IF8.415, 1/25, 4%, Materials science, biomaterials).台灣化學感測器

    科技協會 103 年度傑出論文獎.


  2. Judy Gopal, Hani Abdelhamid, Pei-Yang Hua, Hui-Fen Wu*, Chitosan nanomagnets for effective extraction and sensitive mass spectrometric detection of pathogenic bacterial endotoxin from human urine, Journal of Materials Chemistry B,

    2013, May 1, 2463-2475 (IF6.626/6.743). (Featured in the Journal Back Cover 底頁封

    面報導).


  3. Hani Abdelhamid, Hui-Fen Wu*, Multifunctional graphene magnetic nanosheet decorated with chitosan for hghly sensitive detection of pathogenic bacteria, Journal of Materials Chemistry B, 2013, 1 (32), 3950-3961.


  4. Hani Abdelhamid, Hui-Fen Wu*, Probing the interactions of chitosan capped CdS quantum dots with pathogenic bacteria and their biosensing application. Journal of Materials Chemistry B, 2013, 1 (44), 6094-6106 .


  5. Judy Gopal, Nazim Hasan, Muthu Manikandan, Hui-Fen Wu*,

    Bacterio-toxicity/compatibility of Platinum nanospheres, nanocuboids and nanoflowers, Scientific Reports (Nature Publishing Group), 2013, Feb, 3, 1260, DOI:10.1038/srep01260.(IF5.078).


  6. Judy Gopal, Nazim Hasan, Hui-Fen Wu*, Fabrication of titanium based MALDI bacterial chip for rapid, sensitive and direct analysis of pathogenic bacteria,

    Biosensors and Bioelectronics, 2013, Jan, 39, 57-63. (IF6.451, 1/26, 3.85%, Electrochemistry, 4/73, 5.48%, Chemistry, Analytical).


  7. Hani Abdelhamid, Judy Gopal, Hui-Fen Wu*, Synthesis and application of ionic liquid matrices for effective pathogenic bacteria analysis in Matrix assisted laser desorption/ionization mass spectrometry, Analytica Chimica Acta, 2013, Mar, 767, 104-111 (IF 4.555, 5/73, 6.85%).

    (Highlighted by Sigma-Aldaich: http://www.sigmaaldrich.com/catalog/papers/23452793 and

    http://www.sigmaaldrich.com/catalog/product/aldrich/310905?lang=en&region=TW)


  8. Nazim Hasan, Faheem Ahmad and Hui-Fen Wu*, Heat stress response of Escherichia coli via NiO nanoparticles in MALDI mass spectrometry. Talanta, 2013, 103, 38-46. (IF3.794, 12/73, 16.44%, Chemistry, Analytical).


  9. Muthu Manikandan, Nazim Hasan, Hui-Fen Wu*, Rapid detection of haloarchaeal carotenoids from bacteria via liquid liquid microextraction enabled direct TLC MALDI-MS. Talanta, 2013, Mar, 107, 167-175. (IF3.794, 12/73, 16.44%, Chemistry,

    Analytical).


  10. Judy Gopal, Muthu Manikandan, Nazim Hasan, Chia-Hsun Lee, Hui-Fen Wu*, A comparative study on the mode of interaction of different nanoparticles during MALDI-MS of bacterial cells, Journal of Mass Spectrometry, 2013, Jan, 48,

    119-127. (IF3.289, 7/41, 17.07%, Spectroscopy).


  11. Suresh Kailasa, Hui-Fen Wu*, Surface-assisted laser desorption-ionization mass spectrometry of oligosaccharides using magnesium oxide nanoparticles as a matrix, Microchimica Acta, 2013, 180 (5), 405-413. (IF3.033, 18/73, 24.66%, Chemistry, Analytical).


  12. Faheem Ahmad, Hui-Fen Wu*, Rapid and sensitive detection of bacteria via platinum-labeled antibodies and on-particle ionization and enrichment prior to MALDI-TOF mass spectrometry. Microchimica Acta, 2013, 180 (5), 485-492. (IF3.033, 18/73, 24.66%, Chemistry, Analytical).


  13. Ramaiyan Sekar, Suresh Kailasa, Hani Abdelhamid, Yuan-Chin Chen and Hui-Fen Wu*, Probing the metal complexation reaction of tobramycin with copper (II) and iron

    (III) ions by electrospray ionization mass spectrometry, International Journal of Mass Spectrometry, 2013, Mar, 338, 23-29. (IF2.549, 14/41, 34.15%, Spectroscopy).


  14. Suresh Kailasa, Hui-Fen Wu*, Recent Advances in Mass Spectrometry for the Identification of Neurochemicals and their Metabolites in Biofluids, Current

    Neuropharmacology, 2013, July, 29, 436-464. (IF2.031/5Year:3.084, Hot Topic Issue).


  15. Ramaiyan Sekar, Suresh Kailasa, Wen-Shan Li, Han-Chung Wu, Hui-Fen Wu*, Rapid separation of acetophenone and its monohydroxy isomers by capillary electrophoresis, Chinese Chemical Letters (Elsevier), 2013, 24, 833-836. (IF1.21).


  16. Muthu Manikandan, Hui-Fen Wu*, Rapid probing the fungicidal and biological role of CdS quantum dots in Saccharomyces cereviciae and Candida utilis by

    MALDI-TOF MS. Journal of Nanoparticles Research, 2013, July, 15 (7), 1728-1740. (IF3.287/5Y:3.574, 36.36%, Nanoscience & Nanotechnology).


  17. Suresh Kailasa, Hui-Fen Wu*, Surface modified BaTiO3 Nanoparticles as the matrix for phospholipids and as extracting probes for LLME of hydrophobic proteins in Escherichia coli by MALDI-MS, Talanta, 2013, 114, 283-290. (IF3.794, 12/73, 16.44%, Chemistry, Analytical).


  18. Hani Abdelhamid, Hui-Fen Wu*, Furoic and Mefenamic acids as new matrices for drug and peptide analysis by matrix assisted laser desorption/ionization mass spectrometry, Talanta, 2013, Oct, 115, 442-450. (IF3.794, 12/73, 16.44%, Chemistry, Analytical).


  19. Muthu Manikandan, Hui-Fen Wu*, Rapid differentiation and quantification of live/dead cancer cells using differential photochemical behavior of acridine orange, Photochemical & Photobiological Sciences (RSC), 2013, 12 (11), 1921-1926. (Journal Front Cover 封面報導, IF2.9, 33%, Chemistry, Physical).


  20. Suresh Kailasa, Hui-Fen Wu*, Single drop microextraction for bioanalysis: present and future. Bioanalysis, 2013, Nov, 5 (21), 2593-2596 (IF3.223, 15/59=25.42%, Chemistry/Medical), Editorials Article (with Author Photo).


  21. Suresh Kailasa, Kuang-Hung Cheng, Hui-Fen Wu*, Semiconductor Nanomaterials-based Fluorescence Spectrometric and MALDI Mass Spectrometric Approaches to Proteome Analyses. Materials, 2013, 6, 5763-5795 (IF2.247).


  22. Bo-Sgum Wu, Hui-Fen Wu*, Nanomaterials based biosensors for bacteria and cancer study, Chemistry (the Chin. Chem. Soc., Taipei), 2013, 71, No3, 213-231.


2012


  1. Muthu Manikandan, Hui-Fen Wu*, Nazim Hasan, Cell population based mass spectrometry using platinum nanodots for algal and fungal studies. Biosensors and Bioelectronics, 2012, May, 35, 493-497. (IF5.602, 1/26, 3.85%, Electrochemistry, 4/73, 5.48%, Chemistry, Analytical, Times cited 1).


  2. Chia-Hsun Lee, Judy Gopal, Hui-Fen Wu*, Ionic solution and nanoparticle assisted MALDI-MS as bacterial biosensors for rapid analysis of yogurt, Biosensors and Bioelectronics, 2012, Jan, 31, 77-83 (IF5.602, 1/26, 3.85%, Electrochemistry, 4/73, 5.48%, Chemistry, Analytical). Highlighted in the featured article of “Advances in Engineering”, 2012. (http://advancesinengineering.com/page/2/)


  3. Faheem Ahmad, Mansoor Siddiqui, Olubukola Babalola, Hui-Fen Wu*, Biofunctionalization of nanoparticle assisted mass spectrometry as biosensors for rapid detection of plant associated bacteria, Biosensors and Bioelectronics, 2012, May, 35, 235-242. (IF5.602, 1/26, 3.85%, Electrochemistry, 4/73, 5.48%, Chemistry, Analytical, Times cited 1).


  4. Judy Gopal, Chia-Hsun Lee, Hui-Fen Wu*, Rapid and direct detection of invivo kinetics of pathogenic bacterial infection from mouse blood and urine. Journal of Proteomics, 2012, June, 75, 2972-2982 (IF5.074, 10/71, 14.08%, Biochemical Research Methods).


  5. Suresh Kailasa, Hui-Fen Wu*, Functionalized quantum dots modified with dopamine dithiocarbamate as the matrix for quantification of efavirenz in human plasma and as affinity probes for rapid identification of microwave tryptic digested proteins in MALDI-TOF-MS. Journal of Proteomics, 2012, June, 75, 2924-2933 (IF5.074, Times cited 1).

  6. Hui-Fen Wu*, Judy Gopal, Hani Abdelhamid, Nazim Hasan, Quantum dot applications endowing novelty to analytical proteomics, Proteomics, 2012, Oct, 12, 2949-2961. (IF4.505, 14/72, 19.44%, Biochemical research methods). Invited review article.


  7. Hani Abdelhamid, Hui-Fen Wu*, A method to detect metal-drug complexes and their interactions with pathogenic bacteria via graphene nanosheet assist laser desorption/ionization mass spectrometry and biosensors. Analytica Chimica Acta, 2012, 751, 94-104 (IF 4.555, 5/73, 6.85%).


  8. Hui-Fen Wu*, Judy Gopal, Muthu Manikandan, Future perspective of Nanoparticle interaction laser desorption/ionization mass spectrometry (NPILDI-MS) for rapid, simple, direct and sensitive detection of microorganisms. Journal of Mass Spectrometry, Special feature article-Perspective/Front cover image/Author Biographies (特寫文章/封面報導/人物介紹), 2012, Mar, 47, 355-363. (IF3.289, 7/41,


    17.07%, Spectroscopy).


  9. Judy Gopal, Hui-Fen Wu*, Chia Hsun Lee, Muthu Manikandan, Tracing the pathogen staphylococcus aureus on laboratory ants using physical preconcentration

    coupled ZnO nanoparticle assisted MALDI-TOF MS. Analyst, 2012, Jan, 137 (2), 357-364 (Featured in the back cover image 底頁封面報導) (IF4.23, 8/73, 10.96%).


  10. Kamlesh Shrivas, Hui-Fen Wu*, Rapid and highly sensitive protein extraction via cobalt oxide nanoparticle based liquid-liquid microextraction coupled with MALDI mass spectrometry, Analyst, 2012, Feb, 137 (4), 890-895 (IF4.23, 8/73, 10.96%). (Featured in the inside front cover image 內頁封面報導)


  11. Suresh Kailasa, Hui-Fen Wu*, Dispersive liquid-liquid microextraction using functionalized Mg(OH)2 NPs with oleic acid as hydrophobic affinity probes for the analysis of hydrophobic proteins in bacteria by MALDI-MS, Analyst, 2012, 137 (19), 4490-4496 (IF4.23, 8/73, 10.96%).


  12. Muthu Manikandan, Nazim Hasan, Hui-Fen Wu*, Rapid and direct detection of attomole adenosine triphosphate (ATP) by MALDI MS using rutile titania chips. Analyst, 2012, 137 (21), 5128-5134. (IF4.23, 8/73, 10.96%).


  13. Suresh Kailasa, Hui-Fen Wu*, One-pot synthesis of dopamine dithiocarbamate functionalized gold nanoparticles for quantitative analysis of small molecules and phosphopeptides in SALDI and MALDI-MS. Analyst, 2012, April, 137 (7), 1629-1638. (IF4.23, 8/73, 10.96%, Times cited 2).


  14. Jayaram Narayana, Judy Gopal, Hui-Fen Wu*, Wound infection kinetics probed by MALDI-MS: Rapid profiling of Staphylococcus aureus in mice. Analyst, 2012, July, 137 (14), 3372-3380.


  15. Faheem Ahmad, Judy Gopal, Hui-Fen Wu*, Rapid and highly sensitive detection of single nematode via direct MALDI Mass Spectrometry. Talanta, 2012, May, 93,

    182-185. (IF3.794, 12/73, 16.44%, Chemistry, Analytical, Times cited 1).


  16. Suresh Kailasa, Nazim Hasan, Hui-Fen Wu*, Identification of multiply charged proteins and amino acid clusters by liquid nitrogen assisted spray ionization mass spectrometry, Talanta, 2012, Aug, 97, 539-549. (IF3.794, 12/73, 16.44%, Chemistry, Analytical).


  17. Faheem Ahmad, Hui-Fen Wu*, High resolution detection of bacterial proteins using the Tris-EDTA buffer approach on MALDI-TOF mass spectrometry, Microchimica Acta, 2012, Feb, 176, 311-316. (IF3.033, 18/73, 24.66%, Chemistry, Analytical).

  18. Suresh Kailasa, Hui-Fen Wu*, Rapid enrichment of phosphopeptides by BaTiO3 nanoparticles after microwave-assisted tryptic digest of phosphoproteins, and their identification by MALDI-MS. Microchimica Acta, 2012, Oct, 179, 83-90. (IF3.033).


  19. Gangaraju Gedda, Judy Gopal, Hui-Fen Wu*, ESI-MS and MALDI-MS analysis of extrapolysaccharides of E.coli. Rapid Communications in Mass Spectrometry. 2012, July, 26, 1609-1616. (IF2.79, 13/42, 30.95%, Spectroscopy).


  20. Hui-Fen Wu*, Biochips and tissue chips – integrating biologists, physicist, chemist and material scientists, Joirnal of Biochips & Tissue Chips. Editorial Article. Vol.2, 1st Issue, 2012.


2011


  1. Judy Gopal, Jayaram Narayana, Hui-Fen Wu*, TiO2 nanoparticle assisted Mass spectrometry as biosensor of Staphylococcus aureus, key pathogen in nosocomial infections from air, skin surface and human nasal passage. Biosensors and Bioelectronics, 2011, Sep, 27, 201-206 (Times cited 6).


  2. Judy Gopal, Hui-Fen Wu*, Gangaraju Gedda, Quantifying the degradation of extracellular polysaccharides of Escherichia coli by CdS quantum dots. Journal of Materials Chemistry, 2011, 21, 13445-13451 (IF6.101, 16/225, 7.11%, Materials Science, Multidisciplinary, Times cited 3).


  3. Nazim Hasan, Judy Gopal, Hui-Fen Wu*, Rapid, sensitive and direct analysis of exopolysaccharides from biofilm on aluminum surfaces exposed to sea water using MALDI-TOF MS. Journal of mass spectrometry, 2011, 46, 1160-1167 (IF3.289, 8/42, 19.05%, Spectroscopy).


  4. Judy Gopal, Hui-Fen Wu*, Chia-Hsun Lee, The bifunctional role of Ag nanoparticles on bacteria- a MALDI-MS perspective. Analyst, 2011, Nov, 136, 5077-5083 (Times cited 2).


  5. Faheem Ahmad, Hui-Fen Wu*, Pt nanoparticles prepared in ionic liquid to extract bacteria from plasma via single drop microextraction coupled with MALDI mass spectrometry. Analyst, 2011, Oct, 136, 4020-4027 (Times cited 4).


  6. Kamlesh Shrivas, Kavita Agrawal, Hui-Fen Wu*, Application of platinum nanoparticles as affinity probe and matrix for direct analysis of small biomolecules

    and microwave digested proteins using matrix-assisted laser desorption/ionization mass spectrometry, Analyst, 2011, July, 136, 2852-2857. (Times cited 2)


  7. Nazim Hasan, Hui-Fen Wu*, Highly selective and sensitive enrichment of phosphopeptides via NiO nanoparticles using microwave assisted centrifugation-on particles ionization/enrichment approach in MALDI-MS. Analytical and Bioanalytical Chemistry, 2011, July, 400, 3451-3462. (IF3.841, 9/73, 12.33%, Chemistry, Analytical, Times cited 2).


  8. Hui-Fen Wu*, Feng-Tsai Chung, 3-Mercaptopropionic acid modified ZnSe quantum dots as the matrix for direct SALDI-MS analysis of peptides/proteins from high salt solution, Rapid Communications in Mass Spectrometry, 2011, June, 25,

    1779-1786.


  9. Hui-Fen Wu*, Suresh Kailasa, Chi-Hsien Lin, Single drop microextraction coupled with MALDI mass spectrometry for rapid and direct analysis of hydrophobic peptides from biological samples in high salt solution, Rapid Communications in Mass Spectrometry, 2011, Jan, 25, 307-315.


image

  1. Suresh Kailasa, Hui-Fen Wu*, Semiconductor cadmium sulphide nanoparticles as matrices for peptides and as co-matrices for the analysis of large proteins in MALDI reflectron and linear TOF MS, Rapid Communications in Mass

    Spectrometry, 2011, Jan, 25, 271-280.


  2. Hui-Fen Wu*, Chen-Che Chin, Bo-Min Liu, Yuan-Chin Chen, Chi-Hsien Lin, Kai-Di Chang, Yi-Hsien Lee, Self assembly formation of magic ion of (H2O)20O+: observation of nanoscale cages of oxygenated water clusters induced from iron

image

nanoparticles, Rapid Communications in Mass Spectrometry, 2011, Feb, 25,


410-414.


12. Anita Ethiraj, Hui-Fen Wu*, Judy Gopal, Synthesis and characterization of ultrasmall thioglycerol modified ZnS quantum dots, Journal of the Chinese Chemical Society, 2011, 58, 805-812 (IF 0.718, 99/147, 67.35%, Chemistry, Multidisciplinary)


2010


  1. Judy Gopal, Hui-Fen Wu*, Yi-Hsien Lee, Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry as a rapid and reliable technique for directly evaluating bactericidal activity: Probing the critical concentration of ZnO nanoparticles as affinity probes. Analytical Chemistry, 2010, Dec, 82,

    9617-9621. (IF5.856, 3/73, 4.11%, Times cited 10).


  2. Kamlesh Shrivas, Hui-Fen Wu*, Multifunctional nanoparticles composite for MALDI-MS: Cd2+ doped carbon nanotubes with CdS nanoparticles as the matrix, preconcentrating and accelerating probes of microwave enzymatic digestion of peptides and proteins for direct MALDI-MS analysis. Journal of Mass Spectrometry, 2010, Dec, 45, 1452-1460.(Times cited 2).

  3. Hui-Fen Wu*, Kavita Agrawal, Kamlesh Shrivas, Yi-Hsien Lee, On particle ionization/enrichment of multifunctional nanoprobes: washing/separation-free, acceleration and enrichment of microwave-assisted tryptic digestion of proteins

    via bare TiO2 nanoparticles in ESI-MS and comparing to MALDI-MS, Journal of Mass Spectrometry, 2010, Dec, 45, 1402-1408 (Times cited 2).

  4. Suresh Kailasa, Hui-Fen Wu*, Surface modified silver selinide nanoparticles as extrating probes to improve peptide/protein detection via nanoparticles-based liquid phase microextraction coupled with MALDI mass spectrometry. Talanta, 2010, Dec, 83, 527-534. (Times cited 2).

  5. Yaotang Ke, Suresh Kailasa, Hui-Fen Wu*, Zhen-Yu Chen, High resolution detection of proteins up to 80000 Da via multifunctional CdS quantum dots in laser desorption/ionization mass spectrometry. Talanta, 2010, Nov, 83, 178-184.(Times

    cited 6). Recommanded by Faculty 1000 Biology (F1000-Biology 推薦論文).


  6. Hui-Fen Wu*, Suresh Kailasa, Lokesh Shastri, Electrostatically self


    -assembled –azides on zinc sulfide nanoparticles as multifunctional nanoprobes for peptide and protein analysis in MALDI-TOF MS, Talanta, 2010, July, 82, 540-547 (Times cited 1).

  7. Lokesh Shastri, Suresh Kailasa, Hui-Fen Wu*, Nanoparticle-single drop microextraction as multifunctional and sensitive nanoprobes: Binary matrix approach for gold nanoparticles modified with

    (4-mercaptophenyliminomethyl)-2-methoxyphenol for peptide and protein analysis in MALDI-TOF MS, Talanta, 2010, June, 81, 1176-1182 (Times cited 8).

  8. Li, Shuping; Guo, Zhongxian*; Wu, Hui-Fen*; Liu, Ying; Yang, Zhaoguang; Woo, Chee Hoe, Rapid analysis of Gram-positive bacteria in water via membrane

    filtration coupled with nanoprobe based MALDI-MS, Analytical and Bioanalytical Chemistry, 2010, July, 397, 2465-2476 (Times cited 9).

  9. Nazim Hasan, Hui-Fen Wu*, Yi-Hsien Li, Mohd Nawaz, Two step on particle ionization/enrichment via a washing and separation free approach: multifunctional TiO2 nanoparticles as desalting, accelerating and affinity probes for microwave assisted tryptic digestion of phosphoproteins in ESI-MS and MALDI-MS: comparison with microscale TiO2, Analytical and Bioanalytical Chemistry, 2010,

    Apr, 396, 2919-2929 (Times cited 7). (Selected as “Paper in forefront”前瞻論


    文).


  10. Suresh Kailasa, Hui-Fen Wu*, Multifunctional ZrO2 nanoparticles and ZrO2@SiO2 nanorods for improved MALDI-MS analysis of cyclodextrin, peptide and phosphoprotein. Analytical and Bioanalytical Chemistry, 2010, Feb, 396, 1115-1125 (Times cited 8).

  11. Suresh Kailasa and Hui-Fen Wu*, Interference free detection for small molecules: Probing the Mn2+-doped effect and cysteine capped effect on the ZnS nanoparticles for coccidiostats and peptide analysis in SALDI-TOF MS, Analyst, 2010, Mar, 135, 1115-1123 (Times cited 5).

  12. Abdul Bhat, Hui-Fen Wu*, Synthesis, characterization and application of modified Pd nanoparticles as preconcentration probes for selective enrichment/analysis of proteins via hydrophobic interactions from real world samples using Nanoparticle-Liquid-Liquid Microextraction coupled to

    MALDI-TOF MS. Rapid Communications in Mass Spectrometry, 2010, Dec, 24, 3547-3552 (IF2.79, Times cited:1).

  13. Yaotang Ke, Suresh Kailasa, Hui-Fen Wu*, Mohd Nawaz, Surface modified TiO2 nanoparticles as affinity probes and as matrices for the rapid analysis of phosphopeptides and proteins in MALDI-TOF-MS, Journal of separation science, 2010, Nov, 33, 3400-3408 (IF 2.733, Times cited:2).


2009


  1. Kamlesh Shrivas, Suresh Kailasa, Hui-Fen Wu*, Quantum dots laser desorption/ionization mass spectrometry (QDLDI-MS): multifunctional CdSe quantum dots as the matrix, concentrating probes and acceleration for microwave enzymatic digestion for peptide analysis and high resolution detection of proteins in a linear MALDI-TOF MS, Proteomics, 2009, May, 9, 2656-2667. (IF4.815, 13/71, 18.31%, Biochemical research methods, Times cited 33, Featured in the

    front cover image,封面報導).


    image

  2. Kamlesh Shrivas, Suresh Kailasa, Hui-Fen Wu*, Quantum dots - electrospray ionization mass spectrometry: 3-mercaptopropanic acid capped CdS quantum dots as accelerating and enrichment probes for microwave tryptic digestion of proteins. Rapid Communications in Mass Spectrometry, 2009, 23, 3603-3607.

  3. Lokesh Shastri, Suresh Kailasa, Hui-Fen Wu*, Cysteine-capped ZnSe quantum dots as affinity and accelerating probes for microwave enzymatic digestion of proteins via direct matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis. Rapid Communications in Mass Spectrometry, 2009, Aug, 23, 2247-2252. (Times cited 11).

  4. Yuan-Chin Chen, Hui-Fen Wu*, Revolving hollow fiber-liquid phase microextraction coupled to GC/MS using electron ionization for quantification of five aromatic hydrocarbon isomers, Journal of Separation Science, 2009, Sep, 32, 3013-3019. (Times cited 5, Top 10 articles in BioMedLib).

  5. N. Rahman*, S.N.H. Azmi, Hui-Fen Wu, Nanoparticles and atmospheric pressure-matrix assisted laser desorption/ionization mass spectrometry for peptides and drugs analysis, The Icfai University press Journal of Chemistry, 2009, 2,

7-17.


2008


1. Suresh Kailasa, Kamtaman Kiran, Hui-Fen Wu*, Comparison of ZnS Semiconductor Nanoparticles Capped with Various Functional Groups as the Matrix and Affinity Probes for Rapid Analysis of Cyclodextrins and Proteins in the SALDI-TOF Mass Spectrometry, Analytical Chemistry, 2008, Dec, 80,

9681-9688.(Times cited 44).


2. Kamlesh Shrivas, Hui-Fen Wu*, Modified Silver Nanoparticle as Hydrophobic Affinity Probes for Rapid Analysis of Peptide and Proteins in Biological Samples

by coupling liquid-liquid microextraction with AP-MALDI/ion trap and MALDI/Time of Flight Mass Spectrometry. Analytical Chemistry, 2008, Apr, 80, 2583-2589.(Times cited 49, Top 10 articles in BioMedLib).

  1. Kamlesh Shrivas, Hui-Fen Wu*, Oxidized multiwall carbon nanotubes for quantitative determination of cationic surfactants in water samples using

    AP-MALDI-ion trap Mass Spectrometry. Analytica Chimica Acta, 2008, Nov, 628, 198-203. (IF4.555, 5/73, 6.85%, Times cited 13).

  2. Kamlesh Shrivas, Hui-Fen Wu*, Applications of silver nanoparticles capped with different functional groups as the matrix and affinity probes in SALDI-TOF and AP-MALDI- ion trap mass spectrometry for rapid analysis of sulphur drugs and biothiols in human urine, Rapid Communications in Mass Spectrometry, 2008, Sep, 22, 2863-2872.(Times cited 32).

  3. Putty Sudhir, Kamlesh Shrivas, Zi-Chong Zhou, Hui-Fen Wu*, Single drop microextraction using silver nanoparticles as electrostatic probes for peptide analysis in AP-MALDI/MS and comparison with gold electrostatic probes and silver hydrophobic probes, Rapid Communications in Mass Spectrometry, 2008, Oct, 22, 3076-3086. (Times cited 15, Top 10 articles in BioMedLib).

  4. Kavita Agrawal, Hui-Fen Wu*, Bare silica nanoparticles as concentrating and affinity probes for rapid analysis of aminothiols, lysozyme and peptide mixtures using AP-MALDI/ion trap and MALDI/TOF mass spectrometry, Rapid Communications in Mass Spectrometry, 2008, Feb, 22, 283-290. (Times cited 28).

  5. Kavita Agrawal, Hui-Fen Wu*, Kamlesh Shrivas, Reverse Micelle-Microextraction as concentrating and affinity probes for rapid analysis of thiopeptide in the

    AP-MALDI/ion trap and MALDI/TOF Mass Spectrometry. Rapid Communications in Mass Spectrometry, 2008, May, 22, 1437-1444. (Times

    cited 7).


  6. Kamlesh Shrivas, Hui-Fen Wu*, Functionalized multiwalled carbon nanotubes as a preconcentrating probe for rapid monitoring of cationic dyestuffs in environmental water using AP-MALDI/MS. Journal of Separation Science, 2008, 31,

    3603-3611.


  7. Chih-Hao Yang, Nadeem Khan, Hui-Fen Wu*, Differentiation and quantification of xylene isomers by combining headspace solid-phase microextraction/gas chromatography and self-ion molecule reaction in an ion trap tandem mass spectrometry, Journal of Separation Science, 2008, Sep, 31, 3050-3057. (IF2.733, Times cited 3).

  1. Hui-Fen Wu*, Hsin-Yi Ku, Jyh-Hao Yen, Liquid-phase microextraction for rapid AP-MALDI and quantitation of nortriptyline in biological matrices, Journal of Separation Science, 2008, July, 31, 2288-2294.(IF2.733, Times cited 12, Top 10 articles in BioMedLib).

  2. Hui-Fen Wu*, Jyh-Hao Yen, Dynamic liquid phase nanoextraction coupled to GC/MS for rapid analysis of methoxyacetophenone and anisaldehye isomers in urine. Journal of Separation Science, 2008, July, 31, 2295-2302. (IF2.733, Top 10 articles in BioMedLib, Times cited 2).

  1. Kamlesh Shrivas, Hui-Fen Wu*, Ultrasonication followed by single drop microextraction combined with GC/MS for rapid determination of organochlorine pesticides from fish. Journal of Separation Science, 2008, Feb, 31, 380-386. (Times cited 20).

  2. Yao-Tang Ke, Hui-Fen Wu*, Applications of functional nanoparticles as the affinity probes for analysis of peptides and proteins by coupling solvent microextraction with the MALDI mass spectrometry, Chemistry (the Chin. Chem. Soc., Taipei), 2008, 66, No3, 231-240.


2007


  1. Kamlesh Shrivas, Hui-Fen Wu*, Quantitative bioanalysis of quinine by AP-MALDI/MS assisted with dynamic drop-to-drop solvent microextraction,

    Analytica Chimica Acta, 2007, Dec, 605, 153-158. (IF4.555, 5/73, 6.85%, Times


    cited 18).


  2. Bih-Show Lou, Yuan-Chin Chen, Hui-Fen Wu*, Probing the non-covalent binding interaction of Na+ channel inactivation gate peptide in linker between domain III and IV with 5,5-diphenyhydantoin drug in Electrospray/Ion Trap Tandem Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2007, Dec, 21, 2795-3802.

  3. Kamlesh Shrivas, Hui-Fen Wu*, Rapid determination of caffeine in one drop of beverages and foods using drop to drop solvent microextraction with gas

    chromatography/mass spectrometry, Journal of Chromatography A, 2007, Nov, 1170, 9-14. (IF4.531, 6/73, 8.22%, Times cited 27).

  4. Kavita Agrawal, Hui-Fen Wu*, Drop-to-drop solvent microextraction coupled with gas chromatography mass spectrometry for rapid determination of trimeprazine in urine and blood of rats: application to pharmacokinetic studies. Rapid Communications in Mass Spectrometry, 2007, Oct, 21, 3352-3356.

    Times cited 13.


  5. Shuchen Hsieh*, Hsin-Yi Ku, Yao-Tang Ke, Hui-Fen Wu*, Self-Assembled Monolayer Modified Silicon Substrate to enhance the sensitivity of peptide detection for AP-MALDI Mass Spectrometry. Journal of Mass Spectrometry, 2007, Dec, 42, 1628-1636. (Times cited 11).

  6. Kamlesh Shrivas, Hui-Fen Wu*, A Rapid, Sensitive and Effective Quantitative Method for Simultaneous Determination of Cationic Surfactant mixtures from River and Municipal Waste Water by Direct Combination of Single Drop Microextraction with AP-MALDI Mass Spectrometry Journal of Mass Spectrometry, 2007, Dec, 42, 1637-1644. (Times cited 18).

  7. Kamlesh Shrivas, Hui-Fen Wu*, Single drop microextraction as a concentrating probe for rapid screening of low molecular weight of drugs from human urine using AP-MALDI Mass Spectrometry. Rapid Communications in Mass Spectrometry, 2007, Sep, 21, 3103-3108. (Times cited 26).


2006

  1. Ramaiyan Sekar, Hui-Fen Wu*. Quantification method for analysis of monensin in soil, water and urine by direct combining single drop microextraction with atmospheric pressure matrix assisted laser desorption/ionization mass spectrometry. Analytical Chemistry, 2006, Sep, 78, 6306-6313. (Times cited 26).

  2. Hui-Fen Wu*, Jih-Hao Yen, Chen-Che Chin, Combining drop to drop solvent microextraction (DDSME) with gas chromatography/mass spectrometry using electronic ionization and self-ion/molecule reaction method to determine methoxyacetophenone isomers in one drop of water. Analytical Chemistry, 2006, 78, 1707-1712. (Times cited 31).

  3. Hui-Fen Wu*, Chi-Hsien Lin. Direct combination of immersed single-drop microextraction with atmospheric pressure matrix-assisted laser desorption/ionization tandem mass spectrometry for rapid analysis of a hydrophilic drug via hydrogen-bonding interaction and comparison with liquid-liquid extraction and liquid-phase microextraction using a dual gauge microsyringe with a hollow fiber. Rapid Communications in Mass Spectrometry, 2006, Aug, 20, 2511-2515. (Times cited 20).

  4. Bin-Wei Lai, Bo-Ming Liu, Pradip Malik, Hui-Fen Wu*, Combination of Liquid-Phase Hollow Fiber Membrane Microextraction with Gas Chromatography/Negative Chemical Ionization Mass Spectrometry for the Determination of Dichlorophenol Isomers. Analytica Chimica Acta. 2006, Aug, 576, 61-66. (Times cited 20).

  5. N. Rahman*, S.N.H. Azmi, H. F. Wu, The importance of impurity analysis in pharmaceutical products: an integrated approach, Accreditation and Quality Assurance, Springer Verlag, 2006, 11, 69-74.


2005


P. Sudhir, H.-F. Wu*, Z. C. Zhou, identification of peptides using gold nanoparticles-assisted single drop microextraction coupled with AP-MALDI mass spectrometry. Analytical Chemistry, 2005, 77, 7380-7385.


P. Sudhir, H.-F. Wu*, Z. C. Zhou, An application of electrospray ionization tandem mass spectrometry to probe the interaction of Ca+2/Mg+2/Zn+2 and Cl- with gramicidin A, Rapid Communications in Mass Spectrometry, 2005, 19, 1517-1521.


P. Sudhir, H.-F. Wu*, Z. C. Zhou, Probing the interaction of kojic acid antibiotics with iron (III) chloride by using electrospray tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 2005, 19, 209-212.


H. F. Wu*, Developing chemical ionization, host-guest chemistry, self- ion/molecule reaction, single drop microextraction and electrospray mass spectrometry in an ion trap mass spectrometry, Chemistry (the Chin. Chem. Soc., Taipei). 2004, 62, 443-450.


C. H. Yan, H. F. Wu*, A Liquid-Phase Microextraction Method, combining a Dual Gauge Microsyringe with a Hollow Fiber Membrane for the determination of Organochlorine Pesticides in Water by Gas Chromatography/Ion Trap Mass Spectrometry.Rapid Communications in Mass Spectrometry, 2004/12, 18, 3015-3018.


image

N. Khan, H.-F. Wu*, Analysis of silymarin extracted from commercial dosage forms by combining liquid-liquid extraction with negative electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2004/12, 18, 2960-2962.

B. M. Liu, P. Malik, H. F. Wu*, Single-Drop Microextraction and Gas

Chromatography-Mass Spectrometric Determination of Anisaldehyde Isomers in Human Urine and Blood Serum. Rapid Communications in Mass Spectrometry, 2004/9, 18, 2059-2064.


H. F. Wu*, P. Y. Lin, Ethylenediamine as a liquid reagent to probe the hydrogen - bonding and host guest interaction with crown ethers in an Ion Trap Tandem Mass Spectrometer, Rapid Communications in Mass Spectrometry, 2004/6, 18, 1365-1373.


H. F. Wu*, C. H. Chen, M. T. Wu, Observation of Self - Ion - Molecule Reaction during collisionally activated dissociation in an ion - trap mass spectrometer, Journal of Mass Spectrometry, 2004/4, 39, 396-401.


L. Brewer*, K. Krushwitz, R. Lamoreaux, H.F. Wu, Properties of valuable new intermetallics: Brewer–Engel model applied to the bonding of transition metal dialuminides, Intermetallics, 2003/11, 1103-1109.


H. F.Wu*, W. F. Wu, Comparing differentiation of xylene isomers by electronic ionization, chemical ionization and Self-Ion/Molecule Reactions and the first observation of

methyne addition ions for xylene isomers in Self-Ion/Molecule Reactions for

non-nitrogenated compounds, Rapid Communications in Mass Spectrometry, 2003/11, 17, 2399- 2406.


H. F. Wu*, C. H. Chen, L. C. Lu, Probing the Reaction Mechanisms of Self - Ion/Molecule Reaction for Dopamine in an Ion Trap Mass Spectrometer, Rapid Communications in Mass Spectrometry, 2003/5, 17, 1479-1482.


H. F. Wu*, P. Y. Lin, Probing the Effects of Reagent Gas Pressure and Ion Source Temperature for Dimethyl Ether Chemical Ionization of Tricyclic Antidepressants in an External Source Ion Trap Mass Spectrometer, J. Chin. Chem. Soc., 2003/12, 50,

1251-1257.


H. F. Wu*, Y. J. Chuan, Isomer Differentiation by Combining Gas Chromatography, Selective Self–Ion/ Molecule Reaction and Tandem Mass Spectrometry in an Ion Trap Mass Spectrometer, Rapid Communications in Mass Spectrometry, 2003,

17,1030-1036.

H. F. Wu*, Y. R. Chen, B. W. Lai, Novel observation of total ion chromatogram splitting under positive chemical ionization in an external source Ion Trap Mass Spectrometer, Journal of Mass Spectrometry, 2003, 38,458-459.


HF Wu*, LC Lu, 2002 年諾貝爾化學獎－質譜儀分析技術的突破，開展生化科技新領 域, 科學發展月刊, 2003, 361, 50-53.


H. F. Wu*, S. M. Huan, C. F. Wu, 2002, Conformational Analysis and Binding Affinity Determination for Host-Guest Complexation of Alkali Metal Ion with Bis (Crown Ether)s by Electrospray Mass Spectrometry and Molecular Modeling, European Journal of Mass Spectrometry, 8, 375-380.


H. F. Wu*, C. H. Chen, 2002, Hydroxide and oxygen atom attachment to dichlorophthalic anhydride in negative ion chemical ionization with collisionally activated dissociation in an external source ion trap mass spectrometer, European Journal of Mass Spectrometry, 8, 329-332.


Hui-Fen Wu*, Li-Wei Chen and Chien-Hung Chen, 2001/11, Probing the Reactive Sites for Ion/Molecule Reactions of Anthraquinones with Dimethyl Ether by an External Source Ion Trap Tandem Mass Spectrometer and Computational Chemistry, Rapid Communications in Mass Spectrometry, 15, 1977-1987.


Hui-Fen Wu* and Ming-Yi Ho, 2001, Selective Self - Ion / Molecule Reactions in Both External and Internal Source Ion Trap Mass Spectrometers, Rapid Communications in Mass Spectrometry, 15, 1309-1316.


Hui-Fen Wu*, Chien-Hung Chen and Ming-Yi Ho, 2001, April,“Examination of the Best Pressure Range for Ion/Molecule Reactions of Anthraquinones in an External Source Ion Trap Mass Spectrometer” Analytical Sciences, 17, 515-518.


Hui-Fen Wu*, Li-Wei Chen, Jhen-Chen Wang and Ya-Ping Lin, 2001, February,“Simulation of the Collisional Cooling Effect for Binary and Ternary Buffer Gas Mixtures in a Quadrupole Ion Trap Mass Spectrometer”. European Journal of Mass Spectrometry, 7, 1-6.

Hui-Fen Wu*, 2000, August, “Study of Temperature and Pressure Effect of Negative Chemical Ionization Mass Spectrometry Using Methane and Oxygen as Reagent Gases in an External Source Ion Trap Mass Spectrometer”, Journal of Mass Spectrometry, 35, 1049-1050.


Hui-Fen Wu* and Ya-Ping Lin, 2000, June, “Study of Ion-Molecule Reactions and Collisionally Activated Dissociation of Dopamine and Adrenaline by an Ion Trap Mass Spectrometer with an External Ionization Source. European Journal of Mass Spectrometry, 6, 65-77.


Hui-Fen Wu*, Li-Wei Chen and Ya-Ping Lin, 1999, December, “Simulation of Collisional Cooling Effect in a Quadrupole Ion Trap Mass Spectrometer”. Journal of the Chinese Chemical Society, 46, 923-932.


Hui-Fen Wu* and Ya-Ping Lin, 1999, December, “Determination of Sensitivity of the External Source Ion Trap Tandem Mass Spectrometer Using Dimethyl Ether Chemical Ionization”. Journal of Mass Spectrometry, 34, 1283-1285.


Hui-Fen Wu*and Li-Wei Chen, 1998, October, “Study of Host-Guest Complexation of Alkaline Ion, Aluminum Ion and Transition Metal Ions with Crown Ethers by Fast Atom Bombardment Mass Spectrometry”. Journal of the Chinese Chemical Society, 45,

689-699.


L. Brewer* and H.- F. Wu,1997, “Parameters for Calculation of Properties of Acid-Base Intermetallics”. Proc.-Electrochem. Soc., Volume: 97-39, number: High Temperature Materials Chemistry, p 60-69, (CA:128(7)80209z).


Hui-Fen Wu, Leo Brewer*, 1997, January, “Calculation of Thermodynamic Effect of the Brewer-Engel Generalized Acid - Base Reactions of the 1:1 Intermetallics for Nontransition Metals Al, Mg with Transition Metals”. Journal of Alloys and Compounds, 247,1-8.


    1. Alvarez, H.-F. Wu, C.-C. Liou and J. S. Brodbelt*, 1996, September, “Collisionally Activated Dissociation of Transition Metal Ion/Polyether Complexes in a Quadrupole Ion Trap”. Journal of the American Chemical Society, 118, 9131-9138.

      Hui-Fen Wu, Leo Brewer*, 1996, February, “Calculation of Binary Phase Diagrams of Refractory Metals Ta, W, Tc and Re with Liquid Metals Am, Cm, and Bk by Using a Modification of Regular Solution Theory”. Journal of Phase Equilibria, 17,36-39.


      C.-C.Liou, J. Isbell. H.-F. Wu. J. S. Brodbelt*, R. A. Bartsch, J. C. Lee and J. L. Hallman, 1995, April, “Structually- Selective Gas-Phase Ion-Molecule Reactions of

      Dibenzo-16-Crown-5 Compounds” Journal of Mass Spectrometry, 30,572-580.


      H.-F. Wu, J. S. Brodbelt*, 1995, February , “Gas-Phase Chelation Reactions of Monopositive Cations with Heteroaromatic Ligands”. Inorganic Chemistry, 34, 615 –621.


      H.-F. Wu, J. S. Brodbelt*, 1994, October, “Influence of Heteroatom Donors on the Orders of Relative Gas-Phase Binding Affinities of Macrocyclic Polyethers”. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry , 18, 37-44.


      H.-F. Wu, J. S. Brodbelt*, 1994, July, “The Gas-Phase Complexation of Monovalent Alkaline Earth Metal Ions with Polyethers: Comparision to Alkali Metal Ion and Aluminum Ion Complexation”. Journal of The American Chemical Society, 116,6418-6426.


      C.-C .Liou, H.-F. Wu , J. S. Brodbelt*, 1994, April, “Hydrogen-Bonding Interactions in Gas-Phase Polyether/Ammonium Ion-Complexes”. Journal of The American Society for Mass Spectrometry, 5, 260-273.


      H.-F. Wu, J. S. Brodbelt*, 1993, September, “Comparison of the Orders of Gas-Phase Basicities and Ammonium Ion Affinities of Polyethers by the Kinetic Method and Ligand Exchange Technique.” Journal of The American Society for Mass Spectrometry, 4,718-722.


      H.-F. Wu, J. S. Brodbelt*, 1993, April, “Effects of Reaction Ion Kinetic Energy on Both Endothermic and Exothermic Ion/Molecule Reactions in a Quadrupole Ion Trap Mass Spectrometer.” International Journal of Mass Spectrometry and Ion Processes, 124,175-184.

      H.-F. Wu, J. S. Brodbelt*, 1992, Winter “Effects of Collisional Cooling on Ion Detection in a Quadrupole Ion Trap Mass Spectrometer”. ICR/Ion Trap Newsletter, 25,22-24.


      H.-F. Wu, J. S. Brodbelt*,1992, May, “Effects of Collisional Cooling on Ion Detection in a Quadrupole Ion Trap Mass Spectrometer”. International Journal of Mass Spectrometry and Ion Processes, 115,67-81.


      研討會論文/邀請演講:


      Judy Gopal, Nazim Hasan, H. F. Wu*, Fabrication of TiO2 nanoparticle thin film on titanium surfaces for application as bacterial sensor/biochip for rapid, sensitive and direct analysis of pathogenic bacteria using MALDI-MS, Nano 2012, International Conference & exhibition on nanotechnology & nanomedicine Omics Group, March 12th-14th, Omaha, Nebraska. US. Oral presentation.

      • M. Manikandan, Nazim Hasan, H. F. Wu*, Nanoparticle assisted enhanced biosynthesis of haloarchaeal caroteinoid pigments: Preconcentration of pigments through Pt nanoparticle based liquid liquid microextraction for MALDI-MS analysis. Nano 2012, International Conference & exhibition on nanotechnology &

nanomedicine Omics Group, March 12th-14th, Omaha, Nebraska. US. Oral presentation.


 H. F. Wu*, Nanoparticle interaction laser desorption/ionization mass spectrometry for rapid, simple, direct and sensitive analysis of pathogenic

bacteria, NSYSU & UCSD Symposium, May 19-23, 2012, 中山大學. Invited


Speaker.


 Hui-Fen Wu*, Annual Retreat of the Marine Biotechnology Degree Program, Jan 16, 2012, Invited Speaker.

 H. F. Wu*, J. Gopal, C. H. Lee, Rapid and direct detection of invivo kinetics of pathogenic bacterial infection from mouse blood and urine. 第 2 屆分析蛋白質 體年會.The second International Congress on Analytical Proteomics, Ourense,


Spain. July 18-20, 2011. Invited Speaker and evaluation panel for bacteria/animal for the speech/poster awards.

 Judy Gopal, Jayaram Narayan, Hui-Fen Wu*, TiO2 nanoparticle assisted mass spectrometry for affinity capture of Staphylococcus aureus, the predominant

nosocomial pathogen from air, skin surface and human nasal passage. 第 2 屆亞


洲及太平洋質譜會議.The 2th Asian and Oceanic Mass Spectrometry Conference. Aug. 17-19, 2011, Busan, Korea.

 Chia-Hsun Lee, Judy Gopal, Hui-Fen Wu*, BCrO42- ionic liquid applied in bacterial analysis from fresh and spoilt yogurt.第十七屆分析技術交流研討會, May14-15, 2011.中興大學.

 Hui-Fen Wu*,台俄開發蛋白質體學研究之新穎質譜法研討會, Probing the dual personality of ZnO and Ag nanoparticles in bacteria analysis in MALDI Mass Spectrometry, April 26, 2011, 中山大學 . Invited Speaker.

 Chia-Hsun Lee, Judy Gopal, Hui-Fen Wu*, Mass Spectrometry enabled by a novel Cr6+ containing ionic solution as biosensor of yogurt bacteria.第八屆台灣 質譜年會暨學術研討會, July 10-12, 2011, Sinica.


 Hui-Fen Wu*, Sample pretreatment free mass spectrometry based on nanomaterials,第六屆海峽兩岸分析化學會議.Sep. 9-10, 2010, Da-Lien, China.


Invited Speaker.


 Hui-Fen Wu*, Applications of multifucntional quantum dots and nanoparticle mass spectrometry,台灣質譜學會夏季專題研討會-奈米材料與質譜分析技術, Aug. 13, 2010, 交通大學. Invited Speaker.

 Hui-Fen Wu*, Nanoprobe based mass spectrometry.第三屆世界華人質譜研討會,


2010 年 7 月 30 日-8 月 1 日,吉林省長春市. Invited Speaker.

 Hui-Fen Wu*, 1. Multifunctional nanomaterials for rapid protein and peptide analysis in MALDI, ESI and liquid nitrogen spray mass spectrometry 2. Nanoparticles in ionic liquid-single drop microextraction for highly sensitive and background free detection of bacteria from human plasma in MALDI-MS. 2010,

July 27,台灣大學化學系演講.


 Nazim Hasan, Hui-Fen Wu*, Yi-Hsien Li, Mohd Nawaz, Two step-on particle ionization/enrichment via washing and separation free approach: multifunctional TiO2 nanoparticles as desalting, accelerating and affinity probes for

microwave-tryptic digestion of phosphoproteins in ESI and MALDI-MS: comparing to microscale TiO2, 第 7 屆台灣質譜年會暨學術研討會, 2010, June 27-29, 高雄醫學大學.


 Suresh Kumar Kailasa and Hui-Fen Wu*, Interference free detection for small molecules: Probing the Mn2+-doped effect and cysteine capped effect on the ZnS

nanoparticles for coccidiostats and peptide analysis in SALDI-TOF MS, 第 7 屆


台灣質譜年會暨學術研討會, 2010, June 27-29,高雄醫學大學.


 Lokesh Shastri, Suresh Kumar Kailasa, Hui-Fen Wu*, Nanoparticle-single drop microextraction as multifunctional and sensitive nanoprobes: Binary matrix approach for gold nanoparticles modified with

(4-mercaptophenyliminomethyl)-2-methoxyphenol for peptide and protein analysis in MALDI-TOF MS 第 7 屆台灣質譜年會暨學術研討會, 2010, June 27-29, 高雄醫學大學.

 Suresh K. Kailasa, Hui-Fen Wu*, Multifunctional ZrO2 nanoparticles and ZrO2@SiO2 nanorods for improved MALDI-MS analysis of cyclodextrin, peptide

and phosphoprotein. 第 7 屆台灣質譜年會暨學術研討會, 2010, June 27-29, 高


雄醫學大學.


 Hui-Fen Wu*, Multifunctional nanomaterials for rapid protein and peptide analysis in MALDI and ESI mass spectrometry.第 58 屆日本質譜年會暨第一屆 亞太質譜年會.1st Asian and Oceanic Mass Spectrometry Conference, Japan.


Tsukuba, 2010, June 16-18. Invited Speaker.


 Suresh Kailasa, Hui-Fen Wu*, Improvement of signal intensities for protein analysis with cadmium sulphide nanomaterials as the matrix in MALDI-TOF-MS.

第 58 屆日本質譜年會暨第一屆亞太質譜年會.1st Asian and Oceanic Mass


Spectrometry Conference, Japan. Tsukuba, June 16-18, 2010.


 Nazim Hasan, Hui-Fen Wu*, Highly selective and sensitive enrichment of phosphopeptides via NiO nanoparticles using microwave assisted

centrifugation-on particles ionization/enrichment approach in MALDI-MS. 第 58


屆日本質譜年會暨第一屆亞太質譜年會.1st Asian and Oceanic Mass Spectrometry Conference, Japan. Tsukuba, June 16-18, 2010.

High-Temperature Chemistry, Tilton, New Hampshire, 1996, July 21-26.